Protein transport: The nonclassical ins and outs

Ins and outs of cellular cobalamin transport.

Ins and outs of Ca2+ transport by acidic organelles and cell migration

ARTICLE HISTORY Received 8 May 2017 Accepted 15 May 2017 ABSTRACT Much contemporary evidence underscores the pathophysiological importance of Ca2C handling by acidic organelles such as lysosomes. Whereas our knowledge of how Ca2C is released from these acidic Ca2C stores (the ‘outs’) is advancing, we know relatively little about how Ca2C uptake is effected (the ‘ins’). Here I highlight new work...

Pricing Buy-ins and Buy-outs

Pension buy-ins and buy-outs have become an important aspect of managing pension risk in recent years. As a step toward understanding these pension de-risking instruments, we develop models for pricing investment risk and longevity risk embedded in pension buy-ins and buy-outs. We also bring a contingent-claims framework to price credit risk of buy-in bulk annuities. Overall, our model can be u...

Plant hormones: Ins and outs of auxin transport

Regulated transport has long been known to play a key part in action of the plant hormone auxin. Now, at last, a family of auxin efflux carriers has been identified, and the characterisation of one family member has provided strong evidence in support of models that have been proposed to explain gravitropic curvature in roots.

The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.

Peroxisomes perform a range of metabolic functions which require the movement of substrates, co-substrates, cofactors and metabolites across the peroxisomal membrane. In this review, we discuss the evidence for and against specific transport systems involved in peroxisomal metabolism and how these operate to co-ordinate biochemical reactions within the peroxisome with those in other compartment...